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Article

Genomic loss of the putative tumor suppressor gene E2A in human lymphoma

25 Jul 2011

Abstract excerpt

The transcription factor E2A is essential for lymphocyte development. In this study, we describe a recurrent E2A gene deletion in at least 70% of patients with Sézary syndrome (SS), a subtype of T cell lymphoma. Loss of E2A results in enhanced proliferation and cell cycle progression via derepression of the protooncogene MYC and the cell cycle regulator CDK6. Furthermore, by examining the gene expression profile...

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PMID: 21788410
DOI: 10.1084/jem.20101785

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