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Article

BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines.

Cancer research - 1 Nov 2000

Wong A K, Shanahan F, Chen Y, Lian L, Ha P, Hendricks K, Ghaffari S, Iliev D, Penn B, Woodland A M, Smith R, Salada G, Carillo A, Laity K, Gupte J, Swedlund B, Tavtigian S V, Teng D H, Lees E

Abstract excerpt

Human BRG1 is a component of the evolutionarily conserved SWI-SNF chromatin remodeling complex. BRG1 has been implicated in growth control through its interaction with the tumor suppressor pRb and may consequently serve as a negative regulator of proliferation. Postulating that BRG1 may itself be...

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PMID: 11085541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11085541-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines.PMID 11085541Read ↗

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