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Article

Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis

19 Sept 2007

Abstract excerpt

Deregulation of the Myc pathway and deregulation of the Rb pathway are two of the most common abnormalities in human malignancies. Recent in vitro experiments suggest a complex cross-regulatory relationship between Myc and Rb that is mediated through the control of E2F. To evaluate the functional connection between Myc and E2Fs in vivo, we used a bitransgenic mouse model of Myc-induced T cell lymphomagenesis and...

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PMID: 17881568
DOI: 10.1073/pnas.0706307104

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