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Article

Human sebaceous tumors harbor inactivating mutations in LEF1.

Nature medicine - 1 Apr 2006

Takeda Hikaru, Lyle Stephen, Lazar Alexander J F, Zouboulis Christos C, Smyth Ian, Watt Fiona M

Abstract excerpt

We found that one-third of human sebaceous tumors examined had double-nucleotide substitutions in the same LEF1 allele, irrespective of DNA mismatch repair status. The mutations impaired both LEF1 binding to beta-catenin and transcriptional activation, and are the first tumor-associated mutations...

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PMID: 16565724
DOI: 10.1038/nm1386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16565724-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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