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Article

Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss.

Molecular cell - 1 Apr 2003

Baudino Troy A, Maclean Kirsteen H, Brennan Jennifer, Parganas Evan, Yang Chunying, Aslanian Aaron, Lees Jacqueline A, Sherr Charles J, Roussel Martine F, Cleveland John L

Abstract excerpt

Myc and E2f1 promote cell cycle progression, but overexpression of either can trigger p53-dependent apoptosis. Mice expressing an Emu-Myc transgene in B lymphocytes develop lymphomas, the majority of which sustain mutations of either the Arf or p53 tumor suppressors. Emu-Myc transgenic mice lacking one or both E2f1 alleles exhibited a slower onset of lymphoma development associated with increased expression of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12718877
DOI: 10.1016/s1097-2765(03)00102-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss.PMID 12718877Read ↗

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