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Article

Altered M(1) muscarinic acetylcholine receptor (CHRM1)-Galpha(q/11) coupling in a schizophrenia endophenotype.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 2009

Salah-Uddin Hasib, Scarr Elizabeth, Pavey Geoffrey, Harris Kriss, Hagan Jim J, Dean Brian, Challiss R A John, Watson Jeannette M

Abstract excerpt

Alterations in muscarinic acetylcholine receptor (CHRM) populations have been implicated in the pathology of schizophrenia. Here we have assessed whether the receptor function of the M(1) subtype (CHRM1) is altered in a sub-population of patients with schizophrenia, defined by marked (60-80%) red...

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Source

Identifiers

PMID: 19404243
DOI: 10.1038/npp.2009.41

Genes

CHRM1
PZP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19404243-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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