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Article

Classical and atypical agonists activate M1 muscarinic acetylcholine receptors through common mechanisms.

Pharmacological research - 1 Jul 2015

Randáková Alena, Dolejší Eva, Rudajev Vladimír, Zimčík Pavel, Doležal Vladimír, El-Fakahany Esam E, Jakubík Jan

Abstract excerpt

We mutated key amino acids of the human variant of the M1 muscarinic receptor that target ligand binding, receptor activation, and receptor-G protein interaction. We compared the effects of these mutations on the action of two atypical M1 functionally preferring agonists (N-desmethylclozapine and xanomeline) and two classical non-selective orthosteric agonists (carbachol and oxotremorine). Mutations of D105 in...

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Identifiers

PMID: 25882246
DOI: 10.1016/j.phrs.2015.04.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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