Article
Binding of a tritiated inverse agonist to cannabinoid CB1 receptors is increased in patients with schizophrenia.
Schizophrenia research - 1 Nov 2012
Jenko Kimberly J, Hirvonen Jussi, Henter Ioline D, Anderson Kacey B, Zoghbi Sami S, Hyde Thomas M, Deep-Soboslay Amy, Innis Robert B, Kleinman Joel E
Abstract excerpt
This study sought to determine whether cannabinoid-1 (CB(1)) receptor binding was altered in the postmortem dorsolateral prefrontal cortex (DLPFC) of individuals with schizophrenia (schizophrenia; n=47) compared to controls (n=43). The CB(1) receptor inverse agonist radioligand [(3)H]MePPEP was used to measure specific binding to CB(1) receptors. The specific binding of [(3)H]MePPEP to CB(1) receptors was 20%...
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