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Article

Roles of the lipid-binding motifs of Atg18 and Atg21 in the cytoplasm to vacuole targeting pathway and autophagy.

The Journal of biological chemistry - 9 Apr 2010

Nair Usha, Cao Yang, Xie Zhiping, Klionsky Daniel J

Abstract excerpt

Atg18 and Atg21 are homologous WD-40 repeat proteins that bind phosphoinositides via a novel conserved Phe-Arg-Arg-Gly motif and function in autophagy-related pathways. Atg18 is required for the cytoplasm to vacuole targeting (Cvt) pathway and autophagy, whereas Atg21 is only required for the Cvt pathway. Currently, the functions of both proteins are poorly understood. Here, we examined the relationship between...

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Identifiers

PMID: 20154084
DOI: 10.1074/jbc.M109.080374
PMCID: PMC2857026

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