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Article

Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis.

Autophagy - 1 Feb 2012

Nakatogawa Hitoshi, Ishii Junko, Asai Eri, Ohsumi Yoshinori

Abstract excerpt

Atg8 is a ubiquitin-like protein required for autophagy in the budding yeast Saccharomyces cerevisiae. A ubiquitin-like system mediates the conjugation of the C terminus of Atg8 to the lipid phosphatidylethanolamine (PE), and this conjugate (Atg8-PE) plays a crucial role in autophagosome formation at the phagophore assembly site/pre-autophagosomal structure (PAS). The cysteine protease Atg4 processes the C...

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Identifiers

PMID: 22240591
DOI: 10.4161/auto.8.2.18373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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