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Article

Cargo binding to Atg19 unmasks additional Atg8 binding sites to mediate membrane-cargo apposition during selective autophagy.

Nature cell biology - 1 May 2014

Sawa-Makarska Justyna, Abert Christine, Romanov Julia, Zens Bettina, Ibiricu Iosune, Martens Sascha

Abstract excerpt

Autophagy protects cells from harmful substances such as protein aggregates, damaged mitochondria and intracellular pathogens, and has been implicated in a variety of diseases. Selectivity of autophagic processes is mediated by cargo receptors that link cargo to Atg8 family proteins on the developing autophagosomal membrane. To avoid collateral degradation during constitutive autophagic pathways, the autophagic...

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PMID: 24705553
DOI: 10.1038/ncb2935
PMCID: PMC4009068

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