Article
Hrr25 triggers selective autophagy-related pathways by phosphorylating receptor proteins.
The Journal of cell biology - 13 Oct 2014
Tanaka Chikara, Tan Li-Jing, Mochida Keisuke, Kirisako Hiromi, Koizumi Michiko, Asai Eri, Sakoh-Nakatogawa Machiko, Ohsumi Yoshinori, Nakatogawa Hitoshi
Abstract excerpt
In selective autophagy, degradation targets are specifically recognized, sequestered by the autophagosome, and transported into the lysosome or vacuole. Previous studies delineated the molecular basis by which the autophagy machinery recognizes those targets, but the regulation of this process is still poorly understood. In this paper, we find that the highly conserved multifunctional kinase Hrr25 regulates two...
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