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Article

Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes.

Nature communications - 3 Jul 2020

Mochida Keisuke, Yamasaki Akinori, Matoba Kazuaki, Kirisako Hiromi, Noda Nobuo N, Nakatogawa Hitoshi

Abstract excerpt

The endoplasmic reticulum (ER) is selectively degraded by autophagy (ER-phagy) through proteins called ER-phagy receptors. In Saccharomyces cerevisiae, Atg40 acts as an ER-phagy receptor to sequester ER fragments into autophagosomes by binding Atg8 on forming autophagosomal membranes. During ER-phagy, parts of the ER are morphologically rearranged, fragmented, and loaded into autophagosomes, but the mechanism...

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Identifiers

PMID: 32620754
DOI: 10.1038/s41467-020-17163-y
PMCID: PMC7335187

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