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Atg9A trafficking through the recycling endosomes is required for autophagosome formation

2 Sept 2016

Abstract excerpt

Autophagy is an intracellular degradation pathway conserved in eukaryotes. Among core autophagy-related (Atg) proteins, mammalian Atg9A is the sole multi-spanning transmembrane protein, and both of its N- and C-terminal domains are exposed to the cytoplasm. It is known that Atg9A travels through the trans-Golgi network (TGN) and the endosomal system under nutrient-rich conditions, and transiently localizes to the...

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PMID: 27587839
DOI: 10.1242/jcs.196196

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