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Article

A single charged voltage sensor is capable of gating the Shaker K+ channel.

The Journal of general physiology - 1 May 2009

Gagnon Dominique G, Bezanilla Francisco

Abstract excerpt

We sought to determine the contribution of an individual voltage sensor to Shaker's function. Concatenated heterotetramers of Shaker zH4 Delta(6-46) wild type (wt) in combination with a neutral S4 segment Shaker mutant (mut) with stoichiometries 2wt/2mut and 1wt/3mut were studied and compared with the 4wt concatenated homotetramer. A single charged voltage sensor is sufficient to open Shaker conductance with...

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Identifiers

PMID: 19398775
DOI: 10.1085/jgp.200810082
PMCID: PMC2712970

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Source receipt: pubmed, retrieved 7 Sept 2026.

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