Article
Functional control of heteromeric Kv2.1/6.4 channels by the voltage sensor domain of the silent Kv6.4 subunit.
The Journal of physiology - 1 Jun 2025
Tewari Debanjan, Sattler Christian, Benndorf Klaus
Abstract excerpt
In the activation process of Kv channels, the S4 segment of the voltage-sensing domain (VSD) moves in the outward direction. A conserved phenylalanine in the transmembrane S2 helix of the VSD is viewed as operating as a charge transfer centre (CTC) that interacts with a positively charged arginine of the S4 helix. This phenylalanine is highly sensitive to diverse substitutions. Kv2.1 subunits can form functional...
Topics
- Shab Potassium Channels
- Animals
- KCNQ Potassium Channels
- Humans
- Protein Domains
- Xenopus laevis
- Ion Channel Gating
- HEK293 Cells
- Mutation
- Protein Subunits