Article
MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis.
Circulation - 12 May 2009
Antoniades Charalambos, Shirodaria Cheerag, Leeson Paul, Baarholm Otto A, Van-Assche Tim, Cunnington Colin, Pillai Ravi, Ratnatunga Chandi, Tousoulis Dimitris, Stefanadis Christodoulos, Refsum Helga, Channon Keith M
Abstract excerpt
BACKGROUND: The role of circulating homocysteine as an atherosclerosis risk factor has recently been questioned. However, 5-methyl-tetrahydrofolate (5-MTHF), the circulating metabolite of folic acid participating in homocysteine metabolism, has direct effects on vascular function. We sought to di...
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