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Article

5-methyltetrahydrofolate restores endothelial function in uraemic patients on convective haemodialysis.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 May 2002

Buccianti Gherardo, Raselli Sara, Baragetti Ivano, Bamonti Fabrizia, Corghi Enzo, Novembrino Cristina, Patrosso Cristina, Maggi Franco M, Catapano Alberico L

Abstract excerpt

BACKGROUND: Hyperhomocysteinaemia is an independent risk factor for the development of atherosclerosis. In patients with chronic renal failure, the administration of folic acid or its metabolites reduces but does not normalize plasma homocysteine concentrations. Furthermore, homocysteine induces...

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Share to Homocysteine
Share to Injections, Intravenous

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11981074
DOI: 10.1093/ndt/17.5.857

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11981074-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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5-methyltetrahydrofolate restores endothelial function in uraemic patients on convective haemodialysis.PMID 11981074Read ↗

MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis.Semantic proximity Read ↗

Homocysteine, malondialdehyde and endothelial markers in dialysis patients during low-dose folinic acid therapy.Semantic proximity Read ↗

Hyperhomocysteinaemia, folate and vitamin B12 in unsupplemented haemodialysis patients: effect of oral therapy with folic acid and vitamin B12.Semantic proximity Read ↗

Influence of methylenetetrahydrofolate reductase genotype, exercise and other risk factors on endothelial function in healthy individuals.Semantic proximity Read ↗

Homocysteine and atheromatous renal artery stenosis.Semantic proximity Read ↗

Comparative study of response to treatment with supraphysiologic doses of B-vitamins in hyperhomocysteinemic hemodialysis patients.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase genotype, vitamin B12, and folate influence plasma homocysteine in hemodialysis patients.Semantic proximity Read ↗

Optimization of dietary folate or low-dose folic acid supplements lower homocysteine but do not enhance endothelial function in healthy adults, irrespective of the methylenetetrahydrofolate reductase (C677T) genotype.Semantic proximity Read ↗

Polymorphism in methylenetetrahydrofolate reductase gene: its impact on plasma homocysteine levels and carotid atherosclerosis in ESRD patients receiving hemodialysis.Semantic proximity Read ↗

The C677T MTHFR genotypes influence the efficacy of B9 and B12 vitamins supplementation to lowering plasma total homocysteine in hemodialysis.Semantic proximity Read ↗

Mutation (677 C to T) in the methylenetetrahydrofolate reductase gene aggravates hyperhomocysteinemia in hemodialysis patients.Semantic proximity Read ↗

Influence of dialysis techniques and alternate vitamin supplementation on homocysteine levels in patients with known MTHFR genotypes.Semantic proximity Read ↗

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