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Article

Endothelial cell dysfunction in women with cardiac syndrome X and MTHFR C677T mutation.

The Israel Medical Association journal : IMAJ - 1 Apr 2007

Alroy Sharon, Preis Meir, Barzilai Menashe, Cassel Aliza, Lavie Lena, Halon David A, Amir Ofer, Lewis Basil S, Flugelman Moshe Y

Abstract excerpt

BACKGROUND: The etiology of chest pain with normal epicardial coronary arteries (cardiac syndrome X) seems to be related to endothelial cell dysfunction. Multiple factors are implicated in the pathophysiology, including elevated levels of homocysteine in the blood. Mutations in the MTHFR gene are associated with elevated levels of homocysteine. OBJECTIVES: To test whether abnormal homocysteine metabolism is...

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Identifiers

PMID: 17491230

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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