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Article

Fbxo45 facilitates pancreatic carcinoma progression by targeting USP49 for ubiquitination and degradation

12 Mar 2022

Abstract excerpt

Fbxo45, a conserved F-box protein, comprises of an atypical SKP1, CUL1, F-box protein (SCF) ubiquitin ligase complex that promotes tumorigenesis and development. However, the biological function and molecular mechanisms of Fbxo45 involved in pancreatic carcinogenesis are ambiguous. We conducted several approaches, including transfection, coIP, real-time polymerase chain reaction (RT-PCR), Western blotting,...

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PMID: 35279684
DOI: 10.1038/s41419-022-04675-2

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