Article

Deficiency of murine UFM1-specific E3 ligase causes microcephaly and inflammation

2022-05-17

Abstract excerpt

<title>Abstract</title> <p>The UFM1 conjugation system is a Ubiquitin (Ub) -like modification system that is essential for animal development and normal physiology of multiple tissues and organs. It consists of UFM1, a Ub-like modifier, and the UFM1-specific enzymes (namely E1 enzyme UBA5, E2 enzyme UFC1 E2, and E3 ligases) that catalyze conjugation of UFM1 to its specific protein targets. Clinical studies have i...

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Literature Corpus work: cf407e2a-efac-5838-8363-f302ab78aad0
DOI: 10.21203/rs.3.rs-1559583/v2

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