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Article

Orosomucoid influences the response to antidepressants in major depressive disorder.

Journal of psychopharmacology (Oxford, England) - 1 Apr 2010

Harley J, Roberts R, Joyce P, Mulder R, Luty S, Frampton C, Kennedy M

Abstract excerpt

Orosomucoid, an acute phase protein, carries basic drugs including antidepressants in plasma. Elevated levels have been reported in patients with depression. It has yet to be established whether orosomucoid concentration influences antidepressant response. The orosomucoid gene (ORM1) is polymorphic and the protein isoforms have differing pharmacokinetic properties which could alter plasma profile and blood brain...

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Source

Identifiers

PMID: 19395425
DOI: 10.1177/0269881109105101

Genes

ORM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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