Article
Influence of eight ABCB1 polymorphisms on antidepressant response in a prospective cohort of treatment-free Russian patients with moderate or severe depression: An explorative psychopharmacological study with naturalistic design.
Human psychopharmacology - 1 May 2022
Geers Lisanne M, Ochi Taichi, Vyalova Natalya M, Losenkov Innokentiy S, Paderina Diana Z, Pozhidaev Ivan V, Simutkin German G, Bokhan Nikolay A, Wilffert Bob, Touw Daniël J, Loonen Anton J M, Ivanova Svetlana A
Abstract excerpt
BACKGROUND: Many antidepressants are substrates of P-glycoprotein, an efflux transporter in the blood-brain-barrier encoded by the ABCB1 gene. Genetic variations might influence the transport rate of antidepressants and hence their pharmacological effects. This study investigates the influence of eight polymorphisms in the ABCB1 gene on antidepressant treatment response. METHOD: 152 patients were included from...
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