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Pharmacodynamic profiles inform systematization, efficacy and whole-brain drug distribution profiles in 18 antidepressants

2026-04-29

Abstract excerpt

Although empirical evidence shows that antidepressants are effective and superior to placebo in treating depressive disorders, their mechanisms of action are still unclear. In this study, we examine the multidimensional molecular affinities of 18 commonly used antidepressants. Clustering analyses consistently generate three distinct clusters, providing a broader taxonomy that groups SSRIs and SNRIs together. Corre...

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Literature Corpus work
4d1073a2-2e26-5dd3-97fb-8e3bb16c6681
DOI
10.64898/2026.04.26.720902
Open publication

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Pharmacodynamic profiles inform systematization, efficacy and whole-brain drug distribution profiles in 18 antidepressantsDOI 10.64898/2026.04.26.720902
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