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Article

Canine orosomucoid (alpha-1 acid glycoprotein) variants and their influence on drug plasma protein binding.

Journal of veterinary pharmacology and therapeutics - 1 Jan 2021

Costa Ana P, Court Michael H, Villarino Nicolas F, Burke Neal S, Mealey Katrina L

Abstract excerpt

Orosomucoid polymorphisms influence plasma drug binding in humans; however, canine variants and their effect on drug plasma protein binding have not yet been reported. In this study, the orosomucoid gene (ORM1) was sequenced in 100 dogs to identify the most common variant and its allele frequency determined in 1,464 dogs (from 64 breeds and mixed-breed dogs). Plasma protein binding extent of amitriptyline,...

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Identifiers

PMID: 32744755
DOI: 10.1111/jvp.12899
PMCID: PMC7819641

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