Article
Synaptic scaffolding molecule alpha is a scaffold to mediate N-methyl-D-aspartate receptor-dependent RhoA activation in dendrites.
Molecular and cellular biology - 1 Jun 2007
Iida Junko, Ishizaki Hiroyoshi, Okamoto-Tanaka Miki, Kawata Akira, Sumita Kazutaka, Ohgake Shintaro, Sato Yuji, Yorifuji Hiroshi, Nukina Nobuyuki, Ohashi Kazumasa, Mizuno Kensaku, Tsutsumi Tomonari, Mizoguchi Akira, Miyoshi Jun, Takai Yoshimi, Hata Yutaka
Abstract excerpt
Synaptic scaffolding molecule (S-SCAM) interacts with a wide variety of molecules at excitatory and inhibitory synapses. It comprises three alternative splicing variants, S-SCAMalpha, -beta, and -gamma. We generated mutant mice lacking specifically S-SCAMalpha. S-SCAMalpha-deficient mice breathe and feed normally but die within 24 h after birth. Primary cultured hippocampal neurons from mutant mice have...
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