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Article

Integrin β1 signals through Arg to regulate postnatal dendritic arborization, synapse density, and behavior.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 Feb 2012

Warren M Sloan, Bradley William D, Gourley Shannon L, Lin Yu-Chih, Simpson Mark A, Reichardt Louis F, Greer Charles A, Taylor Jane R, Koleske Anthony J

Abstract excerpt

Integrins are heterodimeric extracellular matrix receptors that are essential for the proper development of the vertebrate nervous system. We report here that selective loss of integrin β1 in excitatory neurons leads to reductions in the size and complexity of hippocampal dendritic arbors, hippocampal synapse loss, impaired hippocampus-dependent learning, and exaggerated psychomotor sensitivity to cocaine in...

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Identifiers

PMID: 22357865
DOI: 10.1523/JNEUROSCI.3942-11.2012
PMCID: PMC3313657

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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