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Article

Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations.

Science (New York, N.Y.) - 2 May 2003

Li Renhao, Mitra Neal, Gratkowski Holly, Vilaire Gaston, Litvinov Rustem, Nagasami Chandrasekaran, Weisel John W, Lear James D, DeGrado William F, Bennett Joel S

Abstract excerpt

Transmembrane helices of integrin alpha and beta subunits have been implicated in the regulation of integrin activity. Two mutations, glycine-708 to asparagine-708 (G708N)and methionine-701 to asparagine-701, in the transmembrane helix of the beta3 subunit enabled integrin alphaIIbbeta3 to constitutively bind soluble fibrinogen. Further characterization of the G708N mutant revealed that it induced alphaIIbbeta3...

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PMID: 12730600
DOI: 10.1126/science.1079441

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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