Article
The conformation of a nascent polypeptide inside the ribosome tunnel affects protein targeting and protein folding.
Molecular microbiology - 1 Oct 2010
Peterson Janine H, Woolhead Cheryl A, Bernstein Harris D
Abstract excerpt
In this report, we describe insights into the function of the ribosome tunnel that were obtained through an analysis of an unusual 25 residue N-terminal motif (EspP(1-25) ) associated with the signal peptide of the Escherichia coli EspP protein. It was previously shown that EspP(1-25) inhibits signal peptide recognition by the signal recognition particle, and we now show that fusion of EspP(1-25) to a cytoplasmic...
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