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Article

lacZ mouse embryonic fibroblasts detect both clastogens and mutagens.

Mutation research - 18 Jun 2009

Mahabir Anuska G, Zwart Edwin, Schaap Mirjam, van Benthem Jan, de Vries Annemieke, Hernandez Lya G, Hendriksen Coenraad F M, van Steeg Harry

Abstract excerpt

The clastogenic effects of MMC and BLM and the mutagenic effects of B[a]P, N-ac-AAF and ENU were studied in mouse embryonic fibroblasts derived from wild-type (WT) and Rad54/Rad54B-deficient mice. Clastogens as well as mutagens showed a statistically significant induction of mutations in the lacZ reporter gene both in a WT and Rad54/Rad54B-deficient genetic background. Rad54/Rad54B MEFs appeared equally sensitive...

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Source

Identifiers

PMID: 19393670
DOI: 10.1016/j.mrfmmm.2009.04.005

Genes

BLM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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