Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evaluation of mutagenic effects of formaldehyde in vitro: detection of crosslinks and mutations in mouse lymphoma cells.

Mutagenesis - 1 May 2002

Speit Günter, Merk Oliver

Abstract excerpt

Formaldehyde (FA) is known to be a genotoxic substance. FA induces DNA-protein crosslinks (DPC) as the primary DNA lesion. However, the significance of DPC for FA-induced mutations and the mechanism(s) of mutation formation are at present poorly understood. Our previous results indicated that FA-induced DPC seem to be related to cytotoxicity and clastogenicity but do not lead to gene mutations in mammalian cells....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Comet Assay
Share to Cross-Linking Reagents
Share to Disinfectants

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Formaldehyde

Share to In Situ Hybridization, Fluorescence

Share to Loss of Heterozygosity

Share to Lymphoma

Share to Mutagens

Source

Identifiers

PMID: 11971987
DOI: 10.1093/mutage/17.3.183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluation of mutagenic effects of formaldehyde in vitro: detection of crosslinks and mutations in mouse lymphoma cells.PMID 11971987Read ↗

Analyses of mutational patterns induced by formaldehyde and acetaldehyde reveal similarity to a common mutational signature.Semantic proximity Read ↗

Mouse lymphoma thymidine kinase gene mutation assay: meeting of the International Workshop on Genotoxicity Testing, San Francisco, 2005, recommendations for 24-h treatment.Semantic proximity Read ↗

Analyses of Mutational Patterns Induced by Formaldehyde and Acetaldehyde Reveal Similarity to a Common Mutational SignatureSemantic proximity Read ↗

The use of L5178Y mouse lymphoma cells to assess the mutagenic, clastogenic and aneugenic properties of chemicals.Semantic proximity Read ↗

In vitro mouse lymphoma (L5178Y Tk⁺/⁻-3.7.2C) forward mutation assay.Semantic proximity Read ↗

Cytogenetic and immunological effects associated with occupational formaldehyde exposure.Semantic proximity Read ↗

In Vitro Mouse Lymphoma Cell (L5178Y Tk+/- 3.7.2C) Forward Mutation Assay.Semantic proximity Read ↗

Detection of Loss of Heterozygosity in Tk-Deficient Mutants from L5178Y Tk+/--3.7.2C Mouse Lymphoma Cells.Semantic proximity Read ↗

Mouse lymphoma thymidine kinase gene mutation assay: follow-up International Workshop on Genotoxicity Test Procedures, New Orleans, Louisiana, April 2000.Semantic proximity Read ↗

Oxidative Stress, Mutations and Chromosomal Aberrations Induced by In Vitro and In Vivo Exposure to Furan.Semantic proximity Read ↗

Genotoxic damage in pathology anatomy laboratory workers exposed to formaldehyde.Semantic proximity Read ↗

Formaldehyde-induced toxicity causes senescence and apoptosis in BMSCs via PI3K/P53 signaling pathwaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.