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Article

Mutation of thyroid hormone receptor-β in mice predisposes to the development of mammary tumors.

Oncogene - 28 Jul 2011

Guigon C J, Kim D W, Willingham M C, Cheng S-Y

Abstract excerpt

Correlative data suggest that thyroid hormone receptor-β (TRβ) mutations could increase the risk of mammary tumor development, but unequivocal evidence is still lacking. To explore the role of TRβ mutants in vivo in breast tumor development and progression, we took advantage of a knock-in mouse model harboring a mutation in the Thrb gene encoding TRβ (Thrb(PV) mouse). Although in adult nulliparous females, a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21399657
DOI: 10.1038/onc.2011.50
PMCID: PMC3457781

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