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Article

AKT1 E17 K pleckstrin homology domain mutation in urothelial carcinoma.

Cancer genetics and cytogenetics - 1 May 2009

Zilberman Dorit E, Cohen Yoram, Amariglio Ninette, Fridman Edward, Ramon Jacob, Rechavi Gideon

Abstract excerpt

The PI3K/AKT pathway is frequently activated in human cancer. Recently, a G to A point mutation (E17K) was found in the pleckstrin homology domain of AKT1. We aimed to explore this mutation in cases of urothelial carcinoma. Using chip-based matrix-assisted laser desorption-time-of-flight (MALDI-TOF) mass spectrometer, AKT1 E17K mutation was searched in 26 total RNA samples obtained from 26 patients known to have...

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Source

Identifiers

PMID: 19389506
DOI: 10.1016/j.cancergencyto.2009.01.009

Genes

AKT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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