Article
Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung.
Cell cycle (Georgetown, Tex.) - 1 Mar 2008
Malanga Donatella, Scrima Marianna, De Marco Carmela, Fabiani Fernanda, De Rosa Nicla, De Gisi Silvia, Malara Natalia, Savino Rocco, Rocco Gaetano, Chiappetta Gennaro, Franco Renato, Tirino Virginia, Pirozzi Giuseppe, Viglietto Giuseppe
Abstract excerpt
Somatic mutation (E17K) that constitutively activates the protein kinase AKT1 has been found in human cancer patients. We determined the role of the E17K mutation of AKT1 in lung cancer, through sequencing of AKT1 exon 4 in 105 resected, clinically annotated non-small cell lung cancer specimens....
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