Article
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer.
Nature - 26 Jul 2007
Carpten John D, Faber Andrew L, Horn Candice, Donoho Gregory P, Briggs Stephen L, Robbins Christiane M, Hostetter Galen, Boguslawski Sophie, Moses Tracy Y, Savage Stephanie, Uhlik Mark, Lin Aimin, Du Jian, Qian Yue-Wei, Zeckner Douglas J, Tucker-Kellogg Greg, Touchman Jeffrey, Patel Ketan, Mousses Spyro, Bittner Michael, Schevitz Richard, Lai Mei-Huei T, Blanchard Kerry L, Thomas James E
Abstract excerpt
Although AKT1 (v-akt murine thymoma viral oncogene homologue 1) kinase is a central member of possibly the most frequently activated proliferation and survival pathway in cancer, mutation of AKT1 has not been widely reported. Here we report the identification of a somatic mutation in human breast, colorectal and ovarian cancers that results in a glutamic acid to lysine substitution at amino acid 17 (E17K) in the...
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