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Article

AKT1 pleckstrin homology domain E17K activating mutation in endometrial carcinoma.

Gynecologic oncology - 1 Jan 2010

Cohen Yoram, Shalmon Bruria, Korach Jacob, Barshack Iris, Fridman Eddie, Rechavi Gideon

Abstract excerpt

OBJECTIVES: The PI3K/AKT pathway is frequently activated in endometrial carcinoma (EC) mainly due to mutations in the PIK3CA and PTEN genes. These events are common and believed to be the key to endometrial carcinogenesis. Recently, a somatic activating mutation in the AKT1 gene (E17K) was identi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19853286
DOI: 10.1016/j.ygyno.2009.09.038

Genes

AKT1
PTEN
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19853286-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Reply: Somatic mutations are present in all members of the AKT family in endometrial carcinomaSemantic proximity Read ↗

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