Article
AKT1(E17K) in human solid tumours.
Oncogene - 18 Sept 2008
Bleeker F E, Felicioni L, Buttitta F, Lamba S, Cardone L, Rodolfo M, Scarpa A, Leenstra S, Frattini M, Barbareschi M, Grammastro M Del, Sciarrotta M G, Zanon C, Marchetti A, Bardelli A
Abstract excerpt
The serine-threonine kinase AKT1 is a central player in the oncogenic pathway controlled by PI3K. Recently, a somatic mutation in AKT1 (E17K) has been detected in breast, colorectal, lung and ovarian cancers. The E17K change results in constitutive AKT1 activation and induces leukaemia in mice. We determined the occurrence of the E17K variant in a panel of 764 tumour samples. These included breast, lung, ovarian,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.