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Article

AKT1 (E17K) mutation in pancreatic cancer.

Technology in cancer research & treatment - 1 Oct 2008

Mohamedali Azim, Lea Nicholas C, Feakins Roger M, Raj Kavita, Mufti Ghulam J, Kocher Hemant M

Abstract excerpt

The prevalence of a novel somatic mutation (E17K) in the pleckstrin homology domain of AKT1 was investigated in pancreatic cancer using a quantitative pyrosequencing assay. This mutation was un-detectable in pancreatic cancer tissue samples (n=65) and pancreatic cell line (n=10) DNA suggesting that pancreatic cancer progression is mainly dependent on the K-Ras mutation.

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Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, ras

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Share to Phosphatidylinositol 3-Kinases

Share to Protein Structure, Tertiary

Share to Proto-Oncogene Proteins c-akt

Source

Identifiers

PMID: 18783292
DOI: 10.1177/153303460800700509

Genes

AKT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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