Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Twist1-Induced Epithelial Dissemination Requires Prkd1 Signaling

1 Nov 2019

Abstract excerpt

Abstract Dissemination is an essential early step in metastasis but its molecular basis remains incompletely understood. To define the essential targetable effectors of this process, we developed a 3D mammary epithelial culture model, in which dissemination is induced by overexpression of the transcription factor Twist1. Transcriptomic analysis and ChIP-PCR together demonstrated that protein kinase D1 (Prkd1) is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Digestive system and related health
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31676574
DOI: 10.1158/0008-5472.can-18-3241

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Twist1-Induced Epithelial Dissemination Requires Prkd1 SignalingPMID 31676574Read ↗

CADM1 is a TWIST1-regulated suppressor of invasion and survivalSemantic proximity Read ↗

TWIST1 expression is associated with high-risk neuroblastoma and promotes primary and metastatic tumor growthSemantic proximity Read ↗

Twist Transcriptionally Up-regulates AKT2 in Breast Cancer Cells Leading to Increased Migration, Invasion, and Resistance to PaclitaxelSemantic proximity Read ↗

ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesionsSemantic proximity Read ↗

TWIST1 Is an ERK1/2 Effector That Promotes Invasion and Regulates MMP-1 Expression in Human Melanoma CellsSemantic proximity Read ↗

Regulation of Cancer Cell Survival, Migration, and Invasion by Twist: AKT2 Comes to InterplaySemantic proximity Read ↗

Snail2 is an Essential Mediator of Twist1-Induced Epithelial Mesenchymal Transition and MetastasisSemantic proximity Read ↗

An epigenetically distinct breast cancer cell subpopulation promotes collective invasionSemantic proximity Read ↗

High TWIST1 mRNA expression is associated with poor prognosis in lymph node-negative and estrogen receptor-positive human breast cancer and is co-expressed with stromal as well as ECM related genesSemantic proximity Read ↗

Shake It Up Baby Now: The Changing Focus on TWIST1 and Epithelial to Mesenchymal Transition in Cancer and Other DiseasesSemantic proximity Read ↗

Post-EMT: Cadherin-11 mediates cancer hijacking fibroblastsSemantic proximity Read ↗

Over-Expressed Twist Associates with Markers of Epithelial Mesenchymal Transition and Predicts Poor Prognosis in Breast Cancers via ERK and Akt ActivationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.