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Article

ETS1 regulates Twist1 transcription in a KrasG12D/Lkb1-/- metastatic lung tumor model of non-small cell lung cancer.

Clinical & experimental metastasis - 1 Mar 2018

Millien Guetchyn, Cao Yuxia, O'Hara Carl J, Tagne Jean-Bosco, Hinds Anne, Williams Mary C, Ramirez Maria I, Kathuria Hasmeena

Abstract excerpt

Distinct members of the Ets family of transcription factors act as positive or negative regulators of genes involved in cellular proliferation, development, and tumorigenesis. In human lung cancer, increased ETS1 expression is associated with poor prognosis and metastasis. We tested whether ETS1 contributes to lung tumorigenesis by binding to Twist1, a gene involved in tumor cell motility and dissemination. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Non-Small-Cell Lung

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Share to Protein Serine-Threonine Kinases

Share to Proto-Oncogene Protein c-ets-1

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Share to Twist-Related Protein 1

Source

Identifiers

PMID: 29909489
DOI: 10.1007/s10585-018-9912-z

Genes

ETS1
TWIST1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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ETS1 regulates Twist1 transcription in a KrasG12D/Lkb1-/- metastatic lung tumor model of non-small cell lung cancer.PMID 29909489Read ↗

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