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Article

The breast cancer susceptibility mutation PALB2 1592delT is associated with an aggressive tumor phenotype.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2009

Heikkinen Tuomas, Kärkkäinen Hanni, Aaltonen Kirsimari, Milne Roger L, Heikkilä Päivi, Aittomäki Kristiina, Blomqvist Carl, Nevanlinna Heli

Abstract excerpt

PURPOSE: To determine the effect of the breast cancer susceptibility mutation PALB2 1592delT on tumor phenotype and patient survival. EXPERIMENTAL DESIGN: We defined the PALB2 mutation status in 947 familial and 1,274 sporadic breast cancer patients and 1,079 population controls, and compared tumor characteristics and survival in mutation carriers relative to other familial and sporadic cases and to 79 BRCA1 and...

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Source

Identifiers

PMID: 19383810
DOI: 10.1158/1078-0432.CCR-08-3128

Genes

PALB2
BRCA2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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