Article
A PALB2 mutation associated with high risk of breast cancer.
Breast cancer research : BCR - 1 Jan 2010
Southey Melissa C, Teo Zhi L, Dowty James G, Odefrey Fabrice A, Park Daniel J, Tischkowitz Marc, Sabbaghian Nelly, Apicella Carmel, Byrnes Graham B, Winship Ingrid, Baglietto Laura, Giles Graham G, Goldgar David E, Foulkes William D, Hopper John L
Abstract excerpt
NTRODUCTION: As a group, women who carry germline mutations in partner and localizer of breast cancer 2 susceptibility protein (PALB2) are at increased risk of breast cancer. Little is known about by how much or whether risk differs by mutation or family history, owing to the paucity of studies of cases unselected for family history. METHODS: We screened 1,403 case probands for PALB2 mutations in a...
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