Article
A common prostate cancer risk variant 5' of microseminoprotein-beta (MSMB) is a strong predictor of circulating beta-microseminoprotein (MSP) levels in multiple populations.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2010
Waters Kevin M, Stram Daniel O, Le Marchand Loic, Klein Robert J, Valtonen-André Camilla, Peltola Mari T, Kolonel Laurence N, Henderson Brian E, Lilja Hans, Haiman Christopher A
Abstract excerpt
BACKGROUND: β-Microseminoprotein (MSP) is one of the three most abundantly secreted proteins of the prostate and has been suggested as a biomarker for prostate cancer risk. A common variant, rs10993994, in the 5' region of the gene that encodes MSP (MSMB) has recently been identified as a risk factor for prostate cancer. METHODS: We examined the association between rs10993994 genotype and MSP levels in a sample...
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