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Article

Nap1l2 promotes histone acetylation activity during neuronal differentiation.

Molecular and cellular biology - 1 Sept 2007

Attia Mikaël, Rachez Christophe, De Pauw Antoine, Avner Philip, Rogner Ute Christine

Abstract excerpt

The deletion of the neuronal Nap1l2 (nucleosome assembly protein 1-like 2) gene in mice causes neural tube defects. We demonstrate here that this phenotype correlates with deficiencies in differentiation and increased maintenance of the neural stem cell stage. Nap1l2 associates with chromatin and interacts with histones H3 and H4. Loss of Nap1l2 results in decreased histone acetylation activity, leading to...

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Identifiers

PMID: 17591696
DOI: 10.1128/MCB.00789-07
PMCID: PMC1952155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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