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Article

Specification of spatial identities of cerebellar neuron progenitors by ptf1a and atoh1 for proper production of GABAergic and glutamatergic neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Apr 2014

Yamada Mayumi, Seto Yusuke, Taya Shinichiro, Owa Tomoo, Inoue Yukiko U, Inoue Takayoshi, Kawaguchi Yoshiya, Nabeshima Yo-Ichi, Hoshino Mikio

Abstract excerpt

In the cerebellum, the bHLH transcription factors Ptf1a and Atoh1 are expressed in distinct neuroepithelial regions, the ventricular zone (VZ) and the rhombic lip (RL), and are required for producing GABAergic and glutamatergic neurons, respectively. However, it is unclear whether Ptf1a or Atoh1 is sufficient for specifying GABAergic or glutamatergic neuronal fates. To test this, we generated two novel knock-in...

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Identifiers

PMID: 24695699
DOI: 10.1523/JNEUROSCI.2722-13.2014
PMCID: PMC6802724

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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