Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ELF4/MEF Activates MDM2 Expression and Blocks Oncogene-Induced p16 Activation To Promote Transformation

21 Apr 2009

Abstract excerpt

Several ETS transcription factors, including ELF4/MEF, can function as oncogenes in murine cancer models and are overexpressed in human cancer. We found that Elf4/Mef activates Mdm2 expression; thus, lack of or knockdown of Elf4/Mef reduces Mdm2 levels in mouse embryonic fibroblasts (mef's), leading to enhanced p53 protein accumulation and p53-dependent senescence. Even though p53 is absent in Elf4(-/-) p53(-/-)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to RNA modifications and cancer
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19380490
DOI: 10.1128/mcb.01551-08

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ELF4/MEF Activates MDM2 Expression and Blocks Oncogene-Induced p16 Activation To Promote TransformationPMID 19380490Read ↗

Roles and regulations of the ETS transcription factor ELF4/MEF.Semantic proximity Read ↗

Myc and E2F1 induce p53 through p14ARF-independent mechanisms in human fibroblastsSemantic proximity Read ↗

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.Semantic proximity Read ↗

Gene expression profiling in melanoma identifies novel downstream effectors of p14ARF.Semantic proximity Read ↗

Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer.Semantic proximity Read ↗

Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2.Semantic proximity Read ↗

Stress-Regulated Transcription Factor ATF4 Promotes Neoplastic Transformation by Suppressing Expression of the INK4a/ARF Cell Senescence FactorsSemantic proximity Read ↗

The LIM-only protein FHL2 mediates ras-induced transformation through cyclin D1 and p53 pathways.Semantic proximity Read ↗

The INK4a/ARF locus in murine tumorigenesis.Semantic proximity Read ↗

Macrophage migration inhibitory factor deficiency is associated with altered cell growth and reduced susceptibility to Ras-mediated transformation.Semantic proximity Read ↗

p14ARF regulates E2F-1 ubiquitination and degradation via a p53-dependent mechanism.Semantic proximity Read ↗

Apoptosis Associated with Deregulated E2F Activity Is Dependent on E2F1 and Atm/Nbs1/Chk2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.