Gene expression profiling in melanoma identifies novel downstream effectors of p14ARF.

Abstract excerpt

p14ARF is inactivated by deletions/mutations in many cancer types and can suppress cell growth by both p53-dependent and p53-independent mechanisms. To identify novel downstream effectors of p14ARF, we used gene expression profiling as a primary screening tool to select candidates for follow up validation studies using in vitro cell-based assays. Gene expression profiles of a panel of 35 melanoma cell lines with...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Core Binding Factor Alpha 1 Subunit
• Share to Gene Expression Profiling