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Article

Genetic analysis of zinc-finger nuclease-induced gene targeting in Drosophila.

Genetics - 1 Jul 2009

Bozas Ana, Beumer Kelly J, Trautman Jonathan K, Carroll Dana

Abstract excerpt

Using zinc-finger nucleases (ZFNs) to cleave the chromosomal target, we have achieved high frequencies of gene targeting in the Drosophila germline. Both local mutagenesis through nonhomologous end joining (NHEJ) and gene replacement via homologous recombination (HR) are stimulated by target cleavage. In this study we investigated the mechanisms that underlie these processes, using materials for the rosy (ry)...

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Identifiers

PMID: 19380480
DOI: 10.1534/genetics.109.101329
PMCID: PMC2710147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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