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Article

Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cells.

Proceedings of the National Academy of Sciences of the United States of America - 31 Oct 2006

Morton Jason, Davis M Wayne, Jorgensen Erik M, Carroll Dana

Abstract excerpt

Zinc-finger nucleases are chimeric proteins consisting of engineered zinc-finger DNA-binding motifs attached to an endonuclease domain. These proteins can induce site-specific DNA double-strand breaks in genomic DNA, which are then substrates for cellular repair mechanisms. Here, we demonstrate that engineered zinc-finger nucleases function effectively in somatic cells of the nematode Caenorhabditis elegans....

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Identifiers

PMID: 17060623
DOI: 10.1073/pnas.0605633103
PMCID: PMC1637589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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