Article
Distribution of MR-induced sex-linked recessive lethal mutations in Drosophila melanogaster.
Mutation research - 1 Jan 2000
Eeken J C, Sobels F H, Hyland V, Schalet A P
Abstract excerpt
In the 'doubling-dose' method currently used in genetic risk evaluation, two principle assumptions are made and these are: (1) there is proportionality between spontaneous and induced mutations and (2) the lesions that lead to spontaneous and induced mutations are essentially similar. The studies reported in this paper were directed at examining the validity of these two assumptions in Drosophila. An analysis was...
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